Introduction: The hospital personnel are exposed to various biological, chemical, physical and psychological hazards. Given the importance of their safety and health, this study was aimed to compare the effect of two teaching methods of lecture and educational package on the nurses’ knowledge of occupational hazards and safety in a hospital in Alborz Province.
Materials and Methods: In a quasi-experimental study, 60 nurses from different departments of Alborz Hospital were randomly divided into educational package and lecture groups. Both groups received training in two 2-hour sessions. The data were collected using a researcher-made questionnaire at three stages of before, after and 3-4 weeks after intervention. The data were analyzed using independent t-test and repeated measures analysis of variance by SPSS-15.
Results: The results indicated that education increased the knowledge of both groups (P=0.001), but there was no significant difference between the two groups immediately after the intervention, and most participants had a high level of knowledge (P=0.692). However, the total mean score of knowledge was significantly higher in the educational package group one month after the intervention (P=0.04). 
Conclusion: According to the results, the provided education persisted more significantly in the educational package group than in the lecture group. Therefore, educational package is suggested to be used for health-related subjects.