Introduction: One of the factors effective on learning being helpful on students’ academic achievement is self-efficacy and motivation. Self-efficacy has powerful effect on motivation, choices, efforts and perseverance eventually leading to academic fulfillment. 
Materials and Methods: This is a descriptive-analytical cross-sectional study on the relationship between educational self-efficacy on one hand and educational motivation on the other among the students of a virtual course in the field of Medical Education at the Shahid Beheshti University of Medical Sciences in 2014-15. It has been done by an all-out counting. Demographic information questionnaire, Zajacova’s self-efficacy and Vallerand’s educational motivation questionnaires have been used as factual data. Eventually, the collected data have been analyzed through Excel 2010 and SPSS version 18. 
Results: Of 149 people who participated in the study, 87.5% were women and 22.4% male; 18.8% were single and 81.2% married; 20.1% were between 25 and 34 years old, 49% were between 35 and 44 years old and 30.9% older than 45. The mean self-efficacy scores of the students have been (5.77 ± 0.07), 75.8% of them being averagely self-efficient. The mean scores for the educational motivation of the participating student have been (53.7 ± 0.07) which shows 68.5% of them have had sufficiently motivated and only few of them were not so while the variables of external and internal motivation always stood high. A positive and direct relationship has been shown between educational self-efficacy and achievement (P<0.05). Self-efficacy and educational motivation proved to be positively and significantly interrelated as well (P<0.05). Various aspects of the educational motivation have not been shown to have statistically significant relationship with various levels of academic achievement according to the study. 
Conclusion: Based on the findings of the study a significant percentage of students have had average to high academic self-efficacy while their educational motivation has been reasonable. Educational self-efficacy has been significantly related to educational motivation, using modern methods of teaching and distance learning as well as effective time management and enhancing motivation eventually can lead to an academic achievement.